Obesity is considered an important trigger of ROS production in sperm cells, which is most probably due to an increased rate of metabolism. Such infections can reduce sperm density and motility, as well as change sperm morphology. Studies have shown that the rate of miscarriages after in vitro fertilization (IVF) is higher in women whose male partners have experienced genitourinary infections. Men with varicocele have higher numbers of sperms with chromatin-related abnormalities, which can be due to increased ROS-induced oxidative stress.īacterial or viral infections in the male reproductive tract can increase the production of ROS. Similarly, smoking can induce ROS production by increasing lipid peroxidation and reducing cellular antioxidant levels.Īnother significant reason for increased ROS production is varicocele, which is defined as an enlargement of the veins in the scrotum. For example, excessive consumption of alcohol can increase the level of certain metabolites that are responsible for increased ROS production in the mitochondria and sperm plasma membrane. Production of ROS in sperm cells can be induced by several factors. In addition, leukocytes, macrophages, and abnormal sperm cells produce a substantial amount of ROS. The two major sites of ROS production in sperm cells are mitochondria and plasma membrane. What are the frequent sources of ROS in semen? This can lead to structural and functional abnormalities in sperm, which subsequently can increase the chance of recurrent miscarriages. Thus, it is obvious that increased sperm DNA damage can impact pregnancy outcomes by negatively affecting placental health.Īlso, a low level of testosterone can negatively impact sperm health by altering spermatogenesis (the process of sperm cell production and development). Sperm DNA plays an important role in placenta formation, and placental health is crucial for fetal survival. However, when produced at higher concentrations, these free radicals can cause DNA damage. In normal physiological conditions, sperm cells produce a low level of ROS (free radicals) to fight against invading microorganisms, such as viruses and bacteria. Impaired functioning of the reproductive hormones together with ROS-induced sperm DNA damage can significantly contribute to recurrent miscarriages. The current findings indicate that recurrent miscarriages are not just a female issue it can also be associated with poor sperm quality. Furthermore, the levels of reactive oxygen species (ROS) in the semen samples of these men are significantly higher than those in healthy counterparts. In addition to having a reduction in serum testosterone and estrogen levels, these men have reduced total and progressive sperm motility and atypical sperm morphology. In this context, a recent study has shown that, compared to healthy couples, women with recurrent miscarriages have male partners whose sperm shows increased levels of DNA damage. To develop appropriate therapeutic interventions to reduce the risk of miscarriage, it is important to identify novel contributing factors. Can recurrent miscarriages occur due to a disorder with the man’s sperm?ĭespite having known risk factors, the reason behind 50 – 75% of recurrent miscarriages remains unidentified. In such cases, an embryo usually receives a disproportionate number of chromosomes, leading to termination of pregnancy. In addition, certain health complications, such as antiphospholipid syndrome, polycystic ovary syndrome, and diabetes mellitus, can make a woman susceptible to recurrent miscarriages.Īnother rare but potential cause of recurrent miscarriages is chromosomal translocation, which is defined as abnormal rearrangement of chromosomes. In this disorder, the uterus is partially separated by a wall of tissue, giving rise to two uterine segments. Women with congenital uterine disorders, such as the septate uterus, are also at higher risk of miscarriages. However, women of higher reproductive age are more susceptible to recurrent miscarriages. Such incidences occur by chance, without any apparent health complications. About 60% of miscarriages occur spontaneously due to abnormal chromosomal distribution during fertilization. Recurrent miscarriages, which affect approximately 1 – 2% of women, are associated with many risk factors. Image Credit: Tatiana Shepeleva/ What are the common causative factors of recurrent miscarriages? However, a recent study has revealed that frequent miscarriages can be associated with poor quality of sperm. Recurrent or repeated miscarriage is defined as the loss of three or more pregnancies before 20 weeks of gestation.įor decades, miscarriage was believed to relate to the woman’s ability to carry a pregnancy to term.
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |